| 董春林,宋 婧,王 元,黄根花,余进进.不同分期子宫内膜癌患者的临床病理特征差异性
及其预后危险因素分析[J].现代生物医学进展英文版,2025,(3):503-510. |
| 不同分期子宫内膜癌患者的临床病理特征差异性
及其预后危险因素分析 |
| Analysis of Clinical and Pathological Differences and Prognostic Risk Factors in Patients with Endometrial Cancer at Different Stages |
| Received:November 10, 2024 |
| DOI：10.13241/j.cnki.pmb.2025.03.014 |
| 中文关键词: 子宫内膜癌 病理特征 危险因素 远处转移 FIGO 分期 生存曲线 |
| 英文关键词: Endometrial cancer Pathological features Risk factors Distant metastasis FIGO installment Survival curve |
| 基金项目:江苏省卫生健康委员会妇幼健康科研项目（F202009）；
无锡市卫生健康委妇幼保健科研项目（FYKY202309）；无锡市'太湖人才计划'医疗卫生高层次人才项目 |
|
| Hits: 0 |
| Download times: 0 |
| 中文摘要: |
| 摘要 目的：分析不同分期子宫内膜癌患者的临床病理特征差异性，并探究子宫内膜的预后危险因素。方法：回顾性选取我院2014年1月~2019年11月收治的128例子宫内膜癌患者临床及病理资料，依照FIGO分期对患者进行分组，Ⅰ期组（78例）、Ⅱ期组（12例）、Ⅲ期组（20例）、Ⅳ期组（18例），比较其一般资料，病理特征情况。并收集所有患者5年门诊复查随访资料，了解患者生存情况，建立数据库，对子宫内膜癌预后相关因素进行分析，并以Kaplan-Meier法建立生存曲线进行检验，分析子宫内膜癌患者不同危险因素的生存曲线情况。结果：不同分期子宫内膜癌患者病理资料对比发现，不同分期子宫内膜癌病理类型、肿瘤直径比较无明显差异（P＞0.05），不同分期子宫内膜癌分化程度、淋巴结转移、远处转移、腹腔细胞学对比差异显著（P＜0.05）；128例患者中5年生存率为72.66%（93/128），不同辅助治疗方式患者5年生存率比较无明显差异（P＞0.05），不同年龄、病理类型、分化程度、淋巴结转移、远处转移、FIGO 分期、手术方式患者5年生存率比较差异显著（P＜0.05）；以5年生存情况作为因变量（5年生存=1，5年死亡=0），将表3中具有统计学查查一的指标作为自变量，实施Logistics回归分析，所有变量一次性纳入模型，结果表明，年龄55岁以上、非子宫内膜样癌、分化程度越高、淋巴结转移、远处转移、FIGO 分期越高为子宫内膜癌预后重要危险因素（P＜0.05）；生存时间以月为单位，比较不同因素下子宫内膜癌生存曲线，结果显示，不同年龄、病理类型、分化程度、淋巴结转移、远处转移及FIGO 分期患者生存情况具有统计学差异（P＜0.05）。结论：不同分期子宫内膜癌患者分化程度、淋巴结转移、远处转移、腹腔细胞学均具有显著差异，且年龄、病理类型、分化程度、淋巴结转移、远处转移及FIGO 分期为影响子宫内膜癌生存期的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the differences in clinical and pathological characteristics of patients with endometrial cancer in different stages, and to explore the prognostic risk factors of endometrial cancer. Methods: Clinical and pathological data of 128 patients with endometrial cancer admitted to our hospital from January 2014 to November 2019 were retrospectively selected. The patients were divided into four groups according to the International Federation of Obstetrics and Gynecology (FIGO) staging: Stage I group (78 cases), stage group (12 cases), stage group (20 cases), and stage group (18 cases). Their general information and pathological characteristics were compared. Collect 5-year outpatient follow-up data from all patients, understand their survival status, establish a database, analyze prognostic factors related to endometrial cancer, and use Kaplan Meier method to establish survival curves for testing. Analyze the survival curves of endometrial cancer patients with different risk factors. Results: Comparing the pathological data of patients with endometrial cancer at different stages, it was found that there was no significant difference in the pathological type and tumor diameter of endometrial cancer at different stages (P>0.05). However, there were significant differences in the differentiation degree, lymph node metastasis, distant metastasis, and peritoneal cytology of endometrial cancer at different stages (P<0.05); The 5-year survival rate among 128 patients was 72.66% (93/128). There was no significant difference in the 5-year survival rate among patients treated with different adjuvant therapies (P>0.05). However, there were significant differences in the 5-year survival rate among patients of different ages, pathological types, differentiation degrees, lymph node metastasis, distant metastasis, FIGO staging, and surgical methods (P<0.05); Using 5-year survival as the dependent variable (5-year survival=1, 5-year death=0) and the indicators with statistical significance in Table 3 as independent variables, Logistics regression analysis was conducted. All variables were included in the model at once. The results showed that age 55 years or older, non endometrial cancer, higher differentiation, lymph node metastasis, distant metastasis, and higher FIGO stage were important risk factors for the prognosis of endometrial cancer (P<0.05); The survival time was measured in months, and the survival curves of endometrial cancer were compared under different factors. The results showed that there were statistically significant differences (P<0.05) in the survival status of patients with different ages, pathological types, differentiation degrees, lymph node metastasis, distant metastasis, and FIGO staging. Conclusion: There are significant differences in differentiation degree, lymph node metastasis, distant metastasis, and peritoneal cytology among patients with endometrial cancer at different stages, and age, pathological type, differentiation degree, lymph node metastasis, distant metastasis, and FIGO stage are risk factors affecting the survival of endometrial cancer. |
|
View Full Text
View/Add Comment Download reader |
| Close |
|
|
|
