| 王利珍,毛现春,樊 森,王保刚,牟丹丹.支气管哮喘合并肺炎支原体感染患儿外周血CX3CL1、CXCL8与肺功能、细胞免疫功能和炎症细胞因子的相关性研究[J].现代生物医学进展英文版,2025,(3):527-534. |
| 支气管哮喘合并肺炎支原体感染患儿外周血CX3CL1、CXCL8与肺功能、细胞免疫功能和炎症细胞因子的相关性研究 |
| Correlation Study between Peripheral Blood CX3CL1, CXCL8and Lung Function, Cellular Immune Function and Inflammatory Cytokines in Children with Bronchial Asthma Complicated with Mycoplasma Pneumoniae Infection |
| Received:November 09, 2024 |
| DOI：10.13241/j.cnki.pmb.2025.03.017 |
| 中文关键词: 支气管哮喘 肺炎支原体感染 CX3CL1 CXCL8 肺功能 细胞免疫功能 炎症细胞因子 |
| 英文关键词: Bronchial asthma Mycoplasma pneumoniae infection CX3CL1 CXCL8 Lung function Cellular immune function Inflammatory cytokines |
| 基金项目:山东省医药卫生科技发展计划项目（2019WSB35012） |
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| 中文摘要: |
| 摘要 目的：分析支气管哮喘合并肺炎支原体（MP）感染患儿外周血不规则趋化因子人驱动蛋白（CX3CL1）、CXC趋化因子配体（CXCL）8与肺功能、细胞免疫功能和炎症细胞因子的相关性。方法：选择我院2022年4月~2024年1月期间收治的180例支气管哮喘患儿作为研究对象，根据是否合并MP感染分为合并组（n=48）和未合并组（n=132）。对比两组治疗前外周血CX3CL1、CXCL8、肺功能指标[用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、FEV1/FVC]、细胞免疫功能指标[CD3+、CD4+、CD8+、CD4+/CD8+]和血清炎症细胞因子[肿瘤坏死因子α（TNF-α）、白细胞介素-6（IL-6）、C反应蛋白（CRP）]。采用Pearson法分析CX3CL1、CXCL8与肺功能、细胞免疫功能和炎症细胞因子的相关性。结果：合并组患儿CX3CL1、CXCL8、TNF-α、CRP、IL-6、CD8+水平高于未合并组（P<0.05）。FVC、FEV1、FEV1/FVC、CD3+、CD4+、CD4+/CD8+低于未合并组（P<0.05）；Pearson相关性分析显示CX3CL1、CXCL8与FVC、FEV1、FEV1/FVC、CD3+、CD4+、CD4+/CD8+呈负相关，与TNF-α、CRP、IL-6、CD8+呈正相关（P<0.05）。结论：支气管哮喘合并MP感染患儿外周血CX3CL1、CXCL8表达异常，与肺功能、细胞免疫功能和炎症细胞因子密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the correlation between peripheral blood irregular chemokine human driver protein (CX3CL1), CXC chemokine ligand (CXCL) 8 and lung function, cellular immune function and inflammatory cytokines in children with bronchial asthma complicated with mycoplasma pneumoniae (MP) infection. Methods: 180 children with bronchial asthma who were admitted to our hospital from April 2022 to January 2024 were selected as the research objects, patients were divided into combined group (n=48) and uncombined group (n=132) according to whether patients were combined with MP infection. Peripheral blood CX3CL1, CXCL8, lung function indexes [forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC], cellular immune function indexes [CD3+, CD4+, CD8+, CD4+/CD8+] and serum inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP)] were compared between two groups before treatment. The correlation between CX3CL1, CXCL8 and lung function, cellular immune function and inflammatory cytokines was analyzed by Pearson method. Results: The levels of CX3CL1, CXCL8, TNF-α, CRP, IL-6 and CD8+ in combined group were higher than those in uncombined group (P<0.05). FVC, FEV1, FEV1/FVC, CD3+, CD4+, CD4+/CD8+ were lower than those in uncombined group (P<0.05). Pearson correlation analysis showed that CX3CL1 and CXCL8 were negatively correlated with FVC, FEV1, FEV1/FVC, CD3+, CD4+ and CD4+/CD8+, and positively correlated with TNF-α, CRP, IL-6 and CD8+ (P<0.05). Conclusion: The abnormal expression of peripheral blood CX3CL1 and CXCL8 in children with bronchial asthma complicated with MP infection is closely related to lung function, cellular immune function and inflammatory cytokines. |
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