| 尹化如,赵金凤,倪卫惠,刘晓丽,王 亮.超声弹性成像评估2型糖尿病患者股浅动脉弹性参数
与动脉粥样硬化进展的相关性研究[J].现代生物医学进展英文版,2025,(3):535-542. |
| 超声弹性成像评估2型糖尿病患者股浅动脉弹性参数
与动脉粥样硬化进展的相关性研究 |
| Study on Correlation between Superficial Femoral Artery Elasticity Parameters Assessed by Ultrasound Elastography and Atherosclerosis Progression in Type 2 Diabetes Mellitus Patients |
| Received:November 17, 2024 |
| DOI：10.13241/j.cnki.pmb.2025.03.018 |
| 中文关键词: 超声弹性成像 2型糖尿病 股浅动脉 动脉粥样硬化 弹性参数 |
| 英文关键词: Ultrasound elastography Type 2 diabetes mellitus Superficial femoral artery Atherosclerosis Elasticity parameters |
| 基金项目:江苏省自然科学基金项目（BK20210028） |
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| 中文摘要: |
| 摘要 目的： 探讨超声弹性成像技术评估2型糖尿病患者股浅动脉弹性参数与动脉粥样硬化进展程度的相关性。方法：选取2021年1月至2023年12月在我院就诊的2型糖尿病患者98例作为研究对象，根据颈动脉内膜中层厚度（IMT）将患者分为单纯糖尿病组（IMT<1.0 mm，32例）、早期动脉硬化组（1.0 mm≤IMT<1.5 mm，34例）和进展期动脉硬化组（IMT≥1.5 mm，32例）。采用超声弹性成像技术测量各组患者股浅动脉弹性参数，包括最大剪切波速度（SWVmax）、最小剪切波速度（SWVmin）和弹性系数（β）。同时检测空腹血糖（FPG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）等生化指标。分析各组患者股浅动脉弹性参数与IMT及生化指标的相关性。结果：（1）三组患者的SWVmax、SWVmin和?茁值比较差异有统计学意义（P<0.05），且随着IMT增加呈递增趋势；（2）相关性分析显示，SWVmax、?茁值与IMT呈显著正相关（r=0.782、0.803，P<0.01），与HbA1c、LDL-C也呈正相关（P<0.05）；（3）多元线性回归分析显示，HbA1c、LDL-C和病程是影响股浅动脉弹性参数的独立危险因素（P<0.05）。结论：超声弹性成像技术能够早期、无创地评估2型糖尿病患者股浅动脉弹性改变，其测得的弹性参数与动脉粥样硬化进展密切相关，可为临床早期预防和干预提供重要依据。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between superficial femoral artery elasticity parameters assessed by ultrasound elastography and the progression of atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods: 98 T2DM patients admitted to our hospital from January 2021 to December 2023 were enrolled. According to carotid intima-media thickness (IMT), patients were divided into simple diabetes group (IMT<1.0 mm, n=32), early atherosclerosis group (1.0 mm≤IMT<1.5 mm, n=34) and progressive atherosclerosis group (IMT≥1.5 mm, n=32). Elasticity parameters of superficial femoral artery including maximum shear wave velocity (SWVmax), minimum shear wave velocity (SWVmin) and stiffness parameter (α) were measured by ultrasound elastography. Biochemical indicators including fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) were also detected. The correlation between arterial elasticity parameters and IMT as well as biochemical indicators was analyzed. Results: (1) There were significant differences in SWVmax, SWVmin and ?茁 values among the three groups (P<0.05), showing an increasing trend with IMT increase; (2) Correlation analysis showed that SWVmax and α were positively correlated with IMT (r=0.782, 0.803, P<0.01) and positively correlated with HbA1c and LDL-C (P<0.05); (3) Multiple linear regression analysis showed that HbA1c, LDL-C and disease duration were independent risk factors affecting arterial elasticity parameters (P<0.05). Conclusion: Ultrasound elastography can early and non-invasively evaluate the elasticity changes of superficial femoral artery in T2DM patients. The measured elasticity parameters are closely related to the progression of atherosclerosis, which can provide important basis for early clinical prevention and intervention. |
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