| Objective: To observe the relationship between preoperative controlling nutritional status (CONUT) score and cognitive impairment, as well as short-term prognosis after intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS). Method: 187 patients with AIS who were admitted to the Third Hospital of Shandong Province from January 2023 to May 2024 were selected, they were divided into non cognitive impairment group (n=106) and cognitive impairment group (n=81) based on whether cognitive impairment occurred, they were divided into poor prognosis group (n=58 cases) and good prognosis group (n=129 cases) according to the prognosis. Preoperative CONUT scores of patients with AIS for different cognitive impairments and prognoses were compared, correlation was analyzed by Spearman rank correlation, influencing factors were analyzed by multivariate logistic regression model. Result: Preoperative CONUT score in the cognitive impairment group was higher than that in the non cognitive impairment group (P<0.05). Preoperative CONUT score in the poor prognosis group was higher than that in the good prognosis group (P<0.05). Spearman rank correlation test results showed that, preoperative CONUT score was positively correlated with cognitive impairment and short-term prognosis after IVT (P<0.05). Cognitive impairment were associated with age, concomitant hypertension, baseline national institutes of health stroke scale (NIHSS) score, and 25 hydroxyvitamin D3 [25- (OH) 2D3] (P<0.05). Age increase, concomitant hypertension, baseline NIHSS score increase, 25- (OH) 2D3 decrease, preoperative CONUT score increase were risk factors for cognitive impairment in patients with AIS (P<0.05). Conclusion: Preoperative CONUT score increase is positively correlated with cognitive impairment and short-term prognosis after IVT. Meanwhile, age increase, concomitant hypertension, baseline NIHSS score increase, 25- (OH) 2D3 decrease, preoperative CONUT score increase are risk factors for cognitive impairment in patient with AIS. |
