Article Summary
社区高血压患者动脉粥样硬化性心血管疾病危险分层及血脂、血压达标的调查研究
Investigation on Risk Stratification of Atherosclerotic Cardiovascular Disease and Target Achievement of Lipid and Blood Pressure in Community-Based Hypertensive Patients
投稿时间:2025-04-15  修订日期:2025-04-15
DOI:
中文关键词: 高血压  动脉粥样硬化性心血管疾病  危险分层  血脂达标  血压达标
英文关键词: Hypertension  Atherosclerotic cardiovascular disease  Risk Stratification  Lipid target achievement  Blood pressure target achievement
基金项目:重庆市璧山区科学技术局2022年第二批社会民生领域科技计划项目(BSKJ0065)
作者单位邮编
彭云丽* 重庆医科大学附属璧山医院全科医学科 402760
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中文摘要:
      目的 本研究旨在调查社区高血压患者的动脉粥样硬化性心血管疾病(ASCVD)危险分层及血脂和血压的达标情况,以期优化社区高血压患者的综合管理策略。方法 本研究纳入了2021年在重庆市璧山区璧城街道社区卫生服务中心建档的2832例高血压患者。通过对健康档案的回顾性分析,收集患者的基线数据,计算非高密度脂蛋白胆固醇(非HDL-C)及估算肾小球滤过率(eGFR),实施ASCVD危险分层,并统计血脂和血压的达标情况以及合并不同并发症的血脂达标情况。结果 根据ASCVD危险分层结果,患者的分布情况为超高危22例(0.78%)、极高危111例(3.92%)、高危1324例(46.75%)、中危997例(35.20%)及低危378例(13.35%)。超高危组的LDL-C达标率为4.55%(1/22),血压达标率为18.18%(4/22);极高危组分别为15.32%(17/111)和11.71%(13/111);高危组的LDL-C达标率仅为4.76%(63/1324),血压达标率为8.08%(107/1324);中危组的LDL-C达标率为25.68%(256/997),血压达标率为26.18%(261/997);低危组的达标率分别为99.74%(377/378)和30.69%(116/378)。合并缺血性脑卒中患者的血脂达标率13.73%(7/51)高于非缺血性脑卒中患者6.40%(178/2781)(P<0.05);合并冠心病患者的血脂达标率12.65%(13/87)高于非冠心病患者6.27%(172/2745)(P<0.05)。合并糖尿病患者的LDL-C达标率为8.04%(52/647),与非糖尿病患者的6.09%(133/2185)比较无差异(P>0.05)。合并慢性肾脏病(CKD) 3/4期患者的LDL-C达标率6.72%(16/238),与非CKD 3/4期患者的6.52%(169/2594)比较无差异(P>0.05)。结论 在社区高血压患者中,ASCVD危险分层高危及以上人群占比超过一半,但其血脂和血压控制水平明显不足。高血压伴合并症的血脂达标率不高,尤其是高血压合并糖尿病和CKD 3/4期的患者。这提示需要将ASCVD危险分层纳入高血压患者社区管理评估中,并加强对高危及以上人群的血脂、血压达标的个性化管理,同时加强对合并糖尿病、CKD 3/4期高血压患者的血脂关注。
英文摘要:
      Objective This study aimed to investigate the atherosclerotic cardiovascular disease (ASCVD) risk stratification and target achievement of lipid and blood pressure control among community-based hypertensive patients,with the goal of optimizing integrated management strategies. Methods A total of 2832 hypertensive patients registered in 2021 at the Bicheng Community Health Service Center in Bishan District of Chongqing,were included.Baseline data were collected through retrospective analysis of health records.Non-high-density lipoprotein cholesterol (non-HDL-C) levels and estimated glomerular filtration rate (eGFR) were calculated. ASCVD risk stratification was performed, and target achievement for lipid and blood pressure control were analyzed, including comparisons among patients with different comorbidities.Results Based on ASCVD risk stratification, patients were categorized as follows: ultra-high risk (22 cases, 0.78%), very high risk (111 cases, 3.92%), high risk (1324 cases, 46.75%), moderate risk (997 cases, 35.20%), and low risk (378 cases, 13.35%). The LDL-C target achievement rate was 4.55% (1/22) in the ultra-high risk group and 15.32% (17/111) in the very high risk group, with blood pressure target achievement rate of 18.18% (4/22) and 11.71% (13/111),respectively.In the high-risk group, LDL-C and blood pressure target achievement rate were only 4.76% (63/1324) and 8.08% (107/1324), while moderate-risk groups showed 25.68% (256/997) and 26.18% (261/997), respectively.The low-risk group achieved 99.74% (377/378) LDL-C target achievement and 30.69% (116/378) blood pressure target achievement. Patients with ischemic stroke had a significantly higher lipid target achievement rate (13.73%, 7/51) compared to non-ischemic stroke patients (6.40%, 178/2781)(P<0.05). Similarly,those with coronary heart disease (12.65%,13/87) exhibited higher lipid target achievement than non-coronary heart disease patients (6.27%,172/2745)(P<0.05). However, no significant difference was observed between hypertensive patients with diabetes (8.04%,52/647) and non-diabetic patients (6.09%, 133/2185)(P>0.05), or between those with chronic kidney disease (CKD) stages 3/4 (6.72%,16/238) and non-CKD 3/4 patients (6.52%,169/2594)(P>0.05).Conclusion Over half of the community-based hypertensive patients were classified as high-risk or above in ASCVD stratification,yet their lipid and blood pressure target achievement rates were markedly suboptimal. Hypertension patients with comorbidities, particularly diabetes or CKD stages 3/4, showed poor lipid target achievement. These findings underscore the necessity of incorporating ASCVD risk stratification into community management assessments for hypertensive patients, enhancing personalized management for high-risk populations, and prioritizing lipid target achievement in those with diabetes or CKD stages 3/4.
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