| Objective To explore the evaluation value of shear wave elastography (SWE) parameters combine with gamma-Glutamyltransferase (GGT) and aspartate aminotransferase (AST)/alanine aminotransferase (ALT) for the severity of cirrhosis patients. Method: 96 cirrhosis patients who were admitted to Dafang County People''s Hospital of Bijie from January 2022 to October 2024 were selected, they were divided into control group (n=65, Child-Push A and B-grade) and an observation group (n=31, Child-Push c-grade) according to Child-Push grade. All cirrhosis patients underwent SWE examination, serum GGT levels, AST/ALT in cirrhosis patients were detected. SWE parameters (shear wave velocity, elastic modulus) and serum GGT levels, AST/ALT were compared between two groups, Pearson correlation analysis was applied to investigate the correlation between SWE parameters, serum GGT, AST/ALT, and the severity of cirrhosis. The receiver operating characteristic (ROC) curve was used to analyze the value of SWE parameters, serum GGT, AST/ALT individual and combined assessment for evaluating Child-Push c-grade cirrhosis. Delong test was used to compare the area under the ROC curve (AUC) of SWE parameter combination, serum GGT and AST/ALT combination, and SWE parameter and serum GGT, AST/ALT combination in evaluating Child-Push c-grade cirrhosis. Results Compared with the control group, the observation group had faster shear wave velocity and higher elastic modulus (P<0.05). The AUC values of shear wave velocity and elastic modulus individual and combined assessment were 0.712, 0.739, and 0.845, respectively. Compared with the control group, the observation group had higher serum GGT, AST, ALT levels, and AST/ALT (P<0.05). The AUC values of serum GGT, AST/ALT individual and combined assessment were 0.664, 0.714, and 0.790, respectively. SWE parameters, serum GGT levels, AST/ALT were positively correlated with the severity of cirrhosis (P<0.05). The AUC of SWE parameter combined with serum GGT and AST/ALT assessment was 0.923, significantly higher than SWE parameter combined and serum GGT and AST/ALT combined (z=2.731, 2.924, both P<0.05). Conclusion: Patients with more severe cirrhosis has a faster shear wave velocity, higher elastic modulus, and higher serum GGT levels and AST/ALT. The combined detection above indicators has good application value in evaluating the degree of cirrhosis. |
