| Objective: To observe the early efficacy of intense pulsed light (IPL) combine with non-ablative fractional laser (NAFL) in preventing postoperative pathological scar formation and intervention of inflammatory factors. Methods: 93 patients with postoperative pathological scar formation who were admitted to our hospital from March 2022 to March 2024 were selected, they were divided into control group A (silicone gel treatment, n=31), control group B (NAFL on the basis of control group A, n=31) and study group (IPL on the basis of control group B, n=31) using the random number table method. The clinical efficacy, simple quality of life scale (SF-36), vancouver scar scale (VSS), inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP)], and adverse reactions among three groups were compared. Result: The clinical total effective rate in the study group were higher than those in the control group A and control group B (P<0.05). SF-36 increased sequentially and VSS decreased sequentially in control group A, control group B, and study group after treatment (P<0.05). CRP, IL-6, and TNF-α decreased sequentially in control group A, control group B, and study group after treatment (P<0.05). There was no significant difference in the incidence of adverse reactions among the three groups (P>0.05). Conclusion: IPL combine with NAFL in preventing postoperative pathological scar formation, can effectively reduce scar formation, reduce inflammatory factors levels, improve patients'' quality of life, and be safe and reliable. |
