| 龚秀平 孙宏伟 蒋 影.咪达唑仑用于上肢创伤病人麻醉前给药的遗忘作用与脑电变化[J].,2006,6(1):32-33 |
| 咪达唑仑用于上肢创伤病人麻醉前给药的遗忘作用与脑电变化 |
| Amnesia effects and EEG changes of midazolam on preanestheticmedication of patients with upper limb trauma |
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| DOI： |
| 中文关键词: 遗忘咪达唑仑 高位硬膜外 脑电描技术 |
| 英文关键词: Amnesia Midazolam Sublimis epidural block( SEB) Electroencephalography( EEG) |
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| 中文摘要: |
| 目的: 评价咪达唑仑用于上肢创伤病人行高位硬膜外阻滞的遗忘作用和相应的脑电变化。方法: 选择40 例单纯上肢
创伤病人行高位硬膜外阻滞随机双盲分为四组: 咪达唑仑0. 15mg/ kg 和0. 10mg/ kg, 安定0. 20mg/ kg, 生理盐水2ml, 麻醉前30 分
钟肌注, 观察用药前后脑电改变, 镇静分级对麻醉操作的遗忘率和程度以及术后心理状况。结果: 用咪达唑仑后, 镇静程度与遗
忘效果有显著变化。0. 10mg/ kg 咪达唑仑的遗忘率为70%, 其中90%为不全遗忘; 0. 15mg/ kg 咪达唑仑可达到100%完全遗忘;
咪达唑仑的脑电功率谱变化为?? 和?? 相对功率明显增加, 而?? 和?? 相对功率明显下降。结论: 肌注咪达唑仑完全可以消除病人
对高位硬膜外麻醉穿刺操作过程的不良回忆, 并与剂量相关。 |
| 英文摘要: |
| Objective: To evaluate the amnesia effects( AE) and corresponding EEG changes of midazolam on the patients with upper limb
trauma( ULT) under sublimis epidural block( SEB) . Methods: 40 patients with ULT under SEB were randomly and double- blindly divided into
four groups. Midazolam 0. 15mg/ kg was given in group A, midazolam 0. 10mg/ kg in group B, diazepam 0. 20mg/ kg in group C and normal saline
2 ml in group D, injecting intramuscularly 30 minutes before anaesthesia. Premedication and postmedication EEG changes, amnesia degrees of
anesthesia procedure of sedative grading and postoperative psychologic status were observed. Results: After giving midazolam, there were signifi??
cant differences in sedative degrees and amnesia effects. Amnesia rate in group B was 70%, of which, 90% of the patients were pero- amnesia;
but amnesia rate in group A reached 100%. EEG power spectrum of midazolam was the increasing of relative power of ??and ??, but the decreasing
of relative power of ??and ??. Conclusion: Midazolam injecting intramuscularly could relieve the patients from the bad recall during the puncture
procedure of SEB,which was related to dose( 0. 10~ 0. 15mg/ kg, IMI, best) , but less dose for the aged. |
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