| 宁刚高杰杨彤涛文艳华杨连甲范清宇马保安.FZD10 在骨肉瘤组织中的表达及临床意义[J].,2011,11(8):1472-1475 |
| FZD10 在骨肉瘤组织中的表达及临床意义 |
| Expression and clinical significance of FZD10 in osteosarcoma |
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| DOI： |
| 中文关键词: 骨肉瘤 FZD10 免疫组织化学 |
| 英文关键词: osteosarcoma FZD10 immunohistochemistry |
| 基金项目:国家自然科学基金面上项目(81072194). |
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| 中文摘要: |
| 目的：探讨骨肉瘤组织中FZD10 的表达及其临床意义。方法：用S-P 免疫组织化学染色法对69 例骨肉瘤及35 例骨软骨瘤
中FZD10 蛋白的表达进行检测,并对其与骨肉瘤临床病理及预后的关系进行统计学分析。结果: FZD10 在骨肉瘤和骨软骨瘤组织
中阳性表达率分别为89.9%和5.7%，P＜0.01。FZD10 蛋白表达与Enneking 分期和Price 分级呈正相关, 与WHO 分型和预后相
关。结论:骨肉瘤FZD10 蛋白的表达与肿瘤恶性程度密切相关,对骨肉瘤诊断和预后评估具有重要价值。 |
| 英文摘要: |
| Objective: To investigate the expression of FZD10 in osteosarcoma and their clinical significance. Methods:The
expression of FZD10 protein was detected by the SP immunohistochemical method in 69 cases of osteosarcoma and 35 cases of
osteochondroma.It's relationship to osteosarcoma clinical pathology and prognosis was analyzed statistically.Results: The positive rates of
FZD10 were 89.9% and 5.7% in osteosarcoma and osteochondroma, respectively (P﹤0.01) .The expression of FZD10 was correlated to
Enneking grade,Price grade,WHO classification and prognosis.Conclusion:The expression of FZD10 protein is closely correlated to
malignant degree.It may serve as a valuable marker for diagnosis and an indicator to predict the prognosis of osteosarcoma. |
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