| 张玉晶赵霞霞杨艳辉田执梁吕莹.磷酸肌酸对新生鼠缺氧缺血性脑损伤线粒体功能的影响[J].,2011,11(21):4040-4042 |
| 磷酸肌酸对新生鼠缺氧缺血性脑损伤线粒体功能的影响 |
| Effect of Phosphocreatine on Mitochondrial in Brain Tissue of Neonate RatsAfter Hypoxia Ischemia Brain Damage（HIBD）* |
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| DOI： |
| 中文关键词: 磷酸肌酸 线粒体 ATP GSH MDA |
| 英文关键词: PCr Mitochondria ATP GSH MDA |
| 基金项目:黑龙江省卫生厅课题（编号2007-324） |
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| 中文摘要: |
| 目的：探讨外源性磷酸肌酸（PCr）在缺氧缺血性脑损伤中对线粒体功能的影响。方法：将96 只七日龄Wistar 新生鼠随机分
为四组，分别为A假手术组、B生理盐水对照组、C磷酸肌酸小剂量干预组、D磷酸肌酸大剂量干预组，每组24只。除假手术组外
其余三组动物制成HIBD模型，并在术前1h分别给予生理盐水、小剂量磷酸肌酸、大剂量磷酸肌酸腹腔注射，24h 后取脑，观察脑
组织线粒体内三磷酸腺苷（ATP）、还原型谷胱甘肽（GSH）以及丙二醛（MDA）的含量变化。结果：外源性磷酸肌酸干预后脑组织中
线粒体内ATP、GSH、MDA含量与盐水对照组相比具有差异性（P＜0.05）。结论：外源性磷酸肌酸可以改善线粒体能量代谢，减轻
脂质过氧化，保护脑组织。 |
| 英文摘要: |
| Objective: To observe the protective effect of phosphovreatine on cerebral mitochondrial membrane in neonate rats
with hypoxic-ischomic brain damage (HIBD). Methods: 96Wistar seven day old rats were randomly assigned into four groups: contrasted
group, 0.9%NaCl contrasted group, PCr group 1 and PCr group 2. Every group was given shanming therapy or 0.9%NaCl or small doze
PCr or large doze PCr before hypoxia-ischemia onset. To observe the contents of ATP on cerebral mitochondrial membrane in neonate
rats. Result: The cerebral ATP、MDA 、GSH contents in the PCr groups were changed significantly ( P＜0.05). Conclusions: PCr protect
brain tissure and improve the energetic metabolism of the mitochondria. |
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