| 许秀安申宝忠△ 王丹孙夕林王凯刘芳.磁敏感加权成像在帕金森病中的应用研究[J].,2011,11(21):4090-4094 |
| 磁敏感加权成像在帕金森病中的应用研究 |
| The SusceptibilityWeighted Imaging Investigation in Patients withParkinson's Disease |
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| DOI： |
| 中文关键词: 磁敏感加权成像 帕金森病 铁 相位值 |
| 英文关键词: SusceptibilityWeighted Imaging Parkinson's disease Iron Phase shift |
| 基金项目: |
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| 中文摘要: |
| 目的：探索帕金森病（PD）的磁敏感加权成像(SWI)的表现。方法：34例帕金森病患者作为病例组和30 例正常人作为对照组，
采用GE1.5T磁共振成像系统，行常规的快速自旋回波T1、T2 加权像后，加扫三维磁敏感加权成像覆盖基底节区及中脑。使用
SWI 后处理软件在校正相位图上两次测量双侧尾状核头、苍白球、壳核、黑质、红核的相位值，最终的相位值取两次测量的平均
值。结果：病例组患者黑质、壳核的相位值较对照组明显降低，差异具有统计学意义（P < 0. 05），PD患者黑质及壳核铁沉积增加。
病例组壳核的相位值与PD病程之间存在负相关。对照组中尾状核头、壳核、黑质相位值左侧低于右侧。结论：SWI是显示PD患
者脑内铁沉积的有效的检查方法。 |
| 英文摘要: |
| Objective: To investigate the Susceptibility Weighted Imaging（SWI）appearance of patients with Parkinson's disease
(PD). Methods: 34 patients with PD (case group) and 30 health person (control group) were chosen. All cases were under conventional
fast-spine echo T1WI, T2WI and 3-dimentional SWI covering basal ganglia and midbrain with GE 1.5T signa MR system. Phase shift of
caput nuclei caudate, globus pallidus, putamen, substantia nigra and red nucleus were detected twice in corrected phase images. The last
phase shift is the average of the twice. Results: The phase shift of case group was obviously lower than that in control group in substantia
nigra and putamen, and the difference have statistical significance (P< 0.05). It illustrate that iron deposition increased in the case group.
The phase shift of putamen had negative correlation with the course of disease in the case group. The caput nuclei caudati, putamen and
substantia nigra's phase shift are lower in left than that in right in the control group. Conclusion: SWI is an effective examination in manifesting
PD's iron deposition. |
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