| 吴欣欣1 玛依努尔·尼牙孜2△.高危型HPV 复制相关蛋白在宫颈组织中的研究[J].,2012,12(7):1391-1393 |
| 高危型HPV 复制相关蛋白在宫颈组织中的研究 |
| Research of High-Risk HPV Replicative Proteins in Cervical Tissue |
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| DOI： |
| 中文关键词: HPV 复制 E1 E2 E7 蛋白 染色体稳定性 |
| 英文关键词: HPV replication E1 E2 E7 Chromosome instability |
| 基金项目:国家自然科学基金项目（81050021) |
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| 中文摘要: |
| 人乳头瘤病毒（Human Papillomavirus,HPV)复制机制的研究，对复制与宫颈病变的相关性可提供重要的依据。HPV 是有衣壳
包裹的小型环状双链DNA 病毒。其基因组可分早期及晚期蛋白编码区和一个调控区。高危型HPV 通过E1、E2 蛋白及Ori 序列
启动复制。高危型HPV 在宫颈上皮细胞中的复制是分化依赖型的，在高危型HPV 感染的成熟的宫颈表皮细胞中，HPV E7 蛋白
使细胞再次进入增殖分裂期，HPV-DNA 得以复制，但同时E7 蛋白亦会诱发宿主细胞染色体不稳定，增加癌变风险。由此推理，
高危型HPV 的复制与宫颈癌的发病有一定相关性。目前有学者对高危型HPV 的复制机制，复制与致癌的关系方面正开展相关研
究。 |
| 英文摘要: |
| The research of HPV replication process can contribute to how how HPV leads to cervical cancer. HPV is a micro
circle double-strand DNA virus with viral particles. HPV-DNA genomes consist of early and late coding regions as well as squences that
regulate trancription and replication. E1and E2 polypeptides and the ori sequences are basic elements to start replication.The replicative
life cycle of HPVs is tightly coupled to the differentiation state of the host keratinocyte, with high level viral genome replication occuring
in differentiated epithelial cellds. E7 protein induces unscheduled DNA replicatin in differentiated keratinocytes. However E7 protein
meanwhile causes chromosome instability and enhances the progress of cancerization. So the replication of HPV is approximately related
to carcinogenesis. Reseaches of replication process and the relationship between replication and carcinogenesis are expending. |
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