| 黄绵庆杨照新王小蒙王世雄符健△.秋茄枝乙醇提取物减轻链脲佐菌素诱导的大鼠肝脏和胰腺病理损伤[J].,2012,12(11):2061-2064 |
| 秋茄枝乙醇提取物减轻链脲佐菌素诱导的大鼠肝脏和胰腺病理损伤 |
| Ethanol Extract from Kandelia Candel Trunk Reduces Pathological Damagesof Liver and Pancreas in Rats Induced by Streptozotocin |
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| DOI： |
| 中文关键词: 秋茄 2 型糖尿病 链脲佐菌素 |
| 英文关键词: Kandelia candel Type 2 diabetes mellitus Streptozotocin |
| 基金项目:海南省自然科学基金项目（309031） |
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| 中文摘要: |
| 目的：研究秋茄枝乙醇提取物（EEK）对链脲佐菌素(STZ)诱导的2 型糖尿病（T2DM）大鼠肝脏和胰腺组织病理结构的影响。
方法：以高脂饲料喂养联合STZ 建立T2DM 大鼠模型。大鼠分为为正常对照组、T2DM 模型组、二甲双胍组、EEK 低、中、高剂量
组。大鼠给药4 周后处死，取肝脏和胰腺进行组织病理学检查。结果：随着EEK 剂量的增加，大鼠肝脏和胰岛组织的病理损伤逐
步减轻。结论：EEK 有助于修复STZ 诱导的T2DM 大鼠受损的肝脏和胰岛组织。 |
| 英文摘要: |
| Objective: To investigate the effect of ethanol extract from kandelia candel trunk (EEK) on pathological structure of
liver and pancreas in type 2 diabetes mellitus (T2DM) rats induced by streptozotocin. Methods: The T2DM rat model was induced with
high-fat diet and STZ. Rats were devided into normal control group, model group, metformin group, EEK low-dose group, EEK
medium-dose group and EEK high-dose group. After 4W administration, the rats were sacrificed to perform histopathological
examination. Results: The pathological damages of liver and pancreas were gradually reduced with increasing dosages of EEK in Rats
Conclusion: EEK contributes to repairing damaged liver and pancreas in T2DM rats induced by STZ. |
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