| 甘思远1 区增冠2 孙艳芹1 陈娟3 陈莉熔2.MRP2 蛋白在食管鳞癌中的表达及其与化疗耐药的相关性[J].,2012,12(25):4863-4865 |
| MRP2 蛋白在食管鳞癌中的表达及其与化疗耐药的相关性 |
| The Expression of MRP2 Protein and its Correlation with theChemoresistance in Esophageal Squamous Cell Carcinoma |
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| DOI： |
| 中文关键词: 食管鳞状细胞癌 免疫组织化学 MTT 多药耐药相关蛋白2 |
| 英文关键词: Esophageal squamous cell carcinoma Immunohistochemistry MTT Multidrug resistance protein 2 |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨MRP2 蛋白在食管鳞癌组织中的表达及其与食管癌化疗耐药的关系。方法：收集原发性食管鳞癌手术标本70
例，采用免疫组织化学Envision 法检测食管鳞癌组织及其癌旁组织中MRP2 蛋白的表达情况，并采用MTT 法检测食管鳞癌组织
对临床常用化疗药物的敏感性，分析其表达与食管癌化疗耐药的关系。结果：70 例食管鳞癌组织及其癌旁正常组织中的阳性表达
率分别为58.6 %及5.0 %。MRP2 蛋白在食管鳞癌组织中的阳性表达率明显高于癌旁正常食管组织(P<0.01)。食管鳞癌组织对环
磷酰胺、5- 氟尿嘧啶、吉西他滨、顺铂、卡铂、阿霉素、长春瑞滨、羟喜树碱等化疗药物的敏感性与其相应癌组织中MRP2 表达明显
相关(P<0.01)。结论：MRP2 的表达与食管鳞癌对多种化疗药物耐药有较好的相关性，推测食管鳞癌组织中MRP2 的高表达可能对
化疗耐药性的发生发展具有促进作用。 |
| 英文摘要: |
| Objective: To investigate the expression of MRP2 protein and its correlation with the chemoresistance in esophageal
squamous cell carcinoma. Methods: 70 cases with esophageal squamous cell carcinomas were chosen. The expression of MRP2 in
esophageal squamous cell carcinomas and pericarcinoma tissues was detected with immunohistochemical Elivision TM plus non-hiotin
technique. The chemoresistace was assayed by MTT method. Results: The positive expression rates of MRP2 protein in esophageal squamous
cell carcinomas and pericarcinoma tissues were 58.6 % and 5.0 % respectively. The positive expression rates of MRP2 protein in
esophageal squamous cell carcinomas were significantly higher than that in pericarcinoma tissues (P<0.01). The expression of MRP2 was
negatively correlated to the chemoresistance, except mitomycin and paclitaxel. Conclusion: The MRP2 protein is overexpressed and the
chemoresistance of the chemotherapeutics probably correlates with the MRP2 expression in esophageal squamous cell carcinomas. |
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