| 朱吉红1 张玉蓉1 肖文辉1 李有秋2 彭耀金2 谭海平3.重度子痫前期患者外周血NK 细胞功能的研究*[J].,2012,12(26):5126-5129 |
| 重度子痫前期患者外周血NK 细胞功能的研究* |
| Research on Peripheral Blood NK Cell Function in SeverePre-Eclamptic Patients* |
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| DOI： |
| 中文关键词: 子痫前期 NK细胞 细胞毒活性 |
| 英文关键词: Pre-eclampsia NK cell Cytotoxic activity |
| 基金项目:湖南省教育厅基金项目资助（09C632） |
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| 中文摘要: |
| 目的：探讨重度子痫前期患者外周血中NK细胞数量、杀伤功能以及相关细胞因子的变化。方法：选择重度子痫前期患者25
例（研究组）以及正常妊娠妇女25 例（对照组），流式细胞术测定外周血中NK 细胞数量，细胞毒实验测定NK 细胞的杀伤活性，
ELISA法测定血清IFN-γ 及IL-2的浓度。结果：研究组患者外周血中NK细胞的数量以及杀伤活性显著高于对照组；研究组外周
血中IFN-γ、IL-2的浓度也显著高于对照组。结论：重度子痫前期患者外周血NK 细胞数量增多，杀伤活性增强，血清中NK 细胞
相关细胞因子也增加。这些改变可能参与重度子痫前期的发病机制。 |
| 英文摘要: |
| Objective: To explore the changes of numbers and cytotoxic activity of NK cell and related cytokines in peripheral
blood of severe pre-eclamptic patients. Methods: 25 severe pre-eclamptic patients (study group) and 25 normal pregnant women (control
group) were included in this study. The rates of NK cell in peripheral blood were measured by flow cytometry. The cytotoxic activity of
NK cell was detected by cytotoxicity assay. The concentrations of serum IFN-γ and IL-2 were determined by ELISA. Results: The rate
and cytotoxic activity of peripheral blood NK cell of study group was significantly higher than that of control group. The serum IFN-γ
and IL-2 levels of study group were also significantly higher than that of control group. Conclusion: The peripheral blood NK cell
number, cytotoxic activity and related cytokines all increased in severe pre-eclamptic patients. These changes may play an important role
in the cause of severe pre-eclampsia. |
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