| 王宇翔 陶树清
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卜建龙.低氧对 MSCs 增殖和分化的影响[J].,2014,14(6):1177-1179 |
| 低氧对 MSCs 增殖和分化的影响 |
| The Impact of Hypoxia on the Proliferation and Differentiation of MSCs |
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| DOI： |
| 中文关键词: 间充质干细胞 低氧 细胞增殖 细胞分化 再生医学 |
| 英文关键词: Mesenchymal stem cells Hypoxia Proliferation Cell differentiation Regenerative Medicine |
| 基金项目: |
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| 中文摘要: |
| 摘要： 间充质干细胞(mesenchymal stem cells, MSCs)是具有自我更新、 多向分化和强可塑性的细胞， 具有分化为血液、 骨、 软骨、 脂
肪、 肌肉、 表皮、 上皮、 神经等组织的潜能， 受到再生医学研究的关注。目前已有研究表明将 MSCs 移植到多种损伤组织中都能改
善损伤组织的功能。文章在简要回顾了低氧环境对 MSCs 增殖和分化的研究内容和有关理论争论基础上重点介绍了缺氧诱导因
子 （ HIF ）通路对 MSCs 增殖和分化的影响。文章阐述了低氧环境对 MSCs 向成骨，成软骨，成脂及成神经元方向分化的影响。 由于
人体组织内生理条件下的氧张力远远小于大气中的氧张力 （21% ）， 采用低氧培养 MSCs 的研究方法得出的结论将更加贴近实际
MSCs 在人体内的增殖、分化情况。因此研究 MSCs 在低氧张力环境中增殖、分化的能力将为 MSCs 能成功移植到体内并发挥作
用提供保障。 |
| 英文摘要: |
| ABSTRACT:Mesenchymal stem cells (mesenchymal stem cells, MSCs) have the function of self-renewal, multi-differentiation and
strong plasticity, which have the potential to differentiation as blood, bone, cartilage, fat, muscle, epidermis, epithelial, nerve tissue, and
have been concerned of regenerationthe medical research. Studies have shown that MSCs transplantation can improve the function of the
damaged tissue toa variety of injured tissues. The article briefly reviews the hypoxic environment on the proliferation and differentiation
of MSCs content and related theory highlights the controversy on the basis of the hypoxia-inducible factor (HIF) pathway on the
proliferation and differentiation of MSCs. The article explains the hypoxic environment of MSCs to differentiate into bone, cartilage,
adipogenic differentiation into neurons affect. Under physiological conditions in human tissue oxygen tension is much less than
atmospheric oxygen tension (21%), hypoxic of MSCs concluded will be closer to the actual MSCs proliferation and differentiation in the
human body. Therefore, study MSCs proliferation, differentiation capacity for MSCs can be successfully transplanted into the body and
play a role in providing protection ina low oxygen tension environment. |
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