| 陈玉龙,张 薇,石明霞,戴凯丽,刘 沛,任 秋.同型半胱氨酸相关性慢性阻塞性肺疾病临床研究进展[J].,2019,19(4):798-800 |
| 同型半胱氨酸相关性慢性阻塞性肺疾病临床研究进展 |
| The Clinical Study and Development between Homocysteinemia and Chronic Obstructive Pulmonary Disease |
| 投稿时间：2018-02-16 修订日期：2018-03-12 |
| DOI：10.13241/j.cnki.pmb.2019.04.043 |
| 中文关键词: 同型半胱氨酸 慢性阻塞性肺疾病 代谢 氧化应激 肺功能 |
| 英文关键词: Homocysteinemia COPD Metabolism Oxidative Pulmonary function |
| 基金项目:黑龙江省教育厅科学技术研究项目（12531235） |
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| 中文摘要: |
| 摘要：在世界慢性疾病中，慢性阻塞性肺疾病（COPD）发病率和死亡率均较高，鉴于对患者生活造成严重伤害，越来越受到人们关注。同型半胱氨酸（Homocysteinemia,Hcy）对全身器官损害多有报道，随着研究的深入，Hcy目前对于肺部疾病的影响也受到重视。部分学者提出同型半胱氨酸可能是COPD 发病机制中又一重要因素。Hcy在体内可以刺激产生大量的ROS和自由离子，并引起内皮细胞应激，还可降低肺脏内还原型谷胱甘肽含量。研究表明同型半胱氨酸水平在慢性阻塞性肺疾病中处于高表达状态，且其高表达水平与患者疾病的程度成相关性。本文将通过总结Hcy在肺脏及体内的代谢、各种应激反应等方面阑述同型半胱氨酸水平与COPD的相关性，并总结高水平的同型半胱氨酸相关的COPD治疗方法。 |
| 英文摘要: |
| ABSTRACT: Chronic Obstructive Pulmonary Disease(COPD) is well-known with the high rate of incidence and mortality worldwide, which leads significant burden, disordered individual's or families' quality of life in a certain degree. Homocysteinemia damages the whole organ system, with the deepening of the research, researchers pay more attention to hcy-related pulmonary diseases. Some scientist puts forward that Hcy maybe a meanningful factor during the pathogenesis of COPD. Part study finds that the plasm of Homocysteinemia in patients with copd is in a high level, even is related to COPD severity. Hcy can produce a large number of ROS and free ions, lead en- dothelial stress, which is regulated by the oxidation of Hcy, also can reduce content of glutathione in the lungs. This article will discuss the metabolic pathways and stress-responest of Hcy in the development of COPD, which all happens to damage the lung. The author also sorts out the latest treatment. |
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