| 佀思聪,杨 伟,罗鸿宇,王洁妤,刘 佳,赵 欢.血清微小RNA-21水平与糖尿病肾病患者氧化应激的相关性研究[J].,2019,19(9):1786-1789 |
| 血清微小RNA-21水平与糖尿病肾病患者氧化应激的相关性研究 |
| Study on the Correlation between Serum miR-21 level and Oxidative Stress in Patients with Diabetic Nephropathy |
| 投稿时间：2019-01-07 修订日期：2019-01-30 |
| DOI：10.13241/j.cnki.pmb.2019.09.041 |
| 中文关键词: 糖尿病肾病 血清 miR-21 氧化应激 相关性 |
| 英文关键词: Diabetic nephropathy Serum miR-21 Oxidative stress Correlation |
| 基金项目:北京市保健专项基金项目（京17-13）；首都医科大学校长培育基金项目（PYZ201844) |
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| 中文摘要: |
| 摘要 目的：探讨血清微小RNA-21（miR-21）水平与糖尿病肾病（DN）患者氧化应激的相关性。方法：选择2015年1月到2017年5月我院就诊的169例DN患者作为研究对象，其中DN分期早期组95例，中晚期组74例。另选同期在我院接受健康体检者90例作为对照组，对比各组血清miR-21水平和氧化应激指标，分析患者血清miR-21水平与氧化应激指标的相关性。结果：各组血清miR-21水平相比差异有统计学意义（P＜0.05），中晚期DN组及早期DN组血清miR-21水平均明显低于对照组，且中晚期DN组又明显低于早期DN组，差异均有统计学意义（P＜0.05）。各组氧化应激指标相比差异有统计学意义（P＜0.05），中晚期DN组及早期DN组丙二醛（MDA）、超氧化物歧化酶（SOD）、晚期氧化蛋白产物（AOPP）及NADPH氧化酶4（NOX4）均明显高于对照组，且中晚期DN组又明显高于早期DN组；而血红素氧合酶1（HO-1）明显低于对照组，且中晚期DN组又明显低于早期DN组，差异均有统计学意义（P＜0.05）。依据Spearman法分析相关性发现，血清miR-21水平与MDA、SOD、AOPP及NOX4均呈负相关（P＜0.05），与HO-1呈正相关（P＜0.05）。结论：血清miR-21水平与DN患者氧化应激指标均具有明显的相关性，临床上可尝试将miR-21纳入到DN患者病情监测的指标体系中，从而有助于疾病的诊治及患者的预后。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum microRNA-21 (miR-21) level and oxidative stress in patients with diabetic nephropathy (DN). Methods: 169 cases of DN patients in our hospital from January 2015 to May 2017 were selected as the study subjects, including 95 cases in early DN group and 74 cases in middle-late DN group. In addition, 90 healthy people who received physical examination in our hospital during the same period were selected as control group. The levels of serum miR-21 and oxidative stress indicators were compared in each group, and the correlation between the levels of serum miR-21 and oxidative stress indicators was analyzed. Results: The levels of serum miR-21 in each group had significant difference (P<0.05). The levels of serum miR-21 in middle-late DN group and early DN group were significantly lower than those in control group, and the levels in middle-late DN group were significantly lower than those in early DN group, the difference was statistically significant (P<0.05). There were significant differ- ences in oxidative stress indicators among the groups (P<0.05), malondialdehyde (MDA), superoxide dismutase (SOD), advanced oxida- tive protein product (AOPP) and NADPH Oxidase 4 (NOX4) in the middle-late DN group and early DN group were significantly higher than those in the control group, and those in the middle-late DN group were significantly higher than those in the early DN group, while heme oxygenase-1 (HO-1) was significantly lower than that of the control group, and in the middle-late DN group was significantly lower than that of the early DN group, the difference was statistically significant (P<0.05). According to Spearman method, serum levels of miR-21 were negatively correlated with MDA, SOD, AOPP and NOX4 (P<0.05), and positively correlated with HO-1 (P<0.05). Conclusion: Serum level of miR-21 is significantly correlated with oxidative stress indicators in DN patients. In clinical practice, miR-21 can be incor- porated into the indicator system of DN patients'condition monitoring, thus contributing to the diagnosis and treatment of diseases and the prognosis of patients. |
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